Fig. 1. Voltage dependence of activation and inactivation of Kv1.3 current in resting and activated lymphocytes. A) Time course of whole cell Kv1.3 current in response to voltage protocols, designed to reveal the inactivation (left) and activation (right) processes in B cells. B) Activation (hollow circles) and inactivation (filled circles) curves, relative Kv1.3 conductance and current, respectively, as a function of voltage in B cells. C) Midpoint potential values for Kv1.3 current in activated and resting B cells as compared to those obtained with T cells. For each cell sample, activation and inactivation curves have been fitted individually and the values of fitted parameters have been averaged for each condition. Data are mean ± SE, n is a total number of tested cells from 3 to 5 different donors for each condition. Different symbols are for significantly different values, significance range from p<0.05 (CD19+ activated vs CD4+ resting) to p<0.0014 (CD19+ resting vs CD4+ resting) for inactivation process and p<0.013 (CD4+ activated vs CD4+ resting) to p<0.0001 (CD19+ resting vs CD4+ resting or vs CD19+ activated) for the activation one.